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Endoscopic Ultrasound-Guided Fine Needle Injection for Cancer Therapy: The Evolving Role of Therapeutic Endoscopic Ultrasound

机译：内镜超声引导下细针注射治疗癌症 治疗：内镜超声治疗的发展作用

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Endoscopic ultrasound (EUS) is central to the diagnosis and staging of many malignancies, but now has an evolving role in cancer therapy. EUS-guided fine needle injection (FNI) is already used for palliative interventions such as treatment of pain through nerve blockade and to guide biliary decompression when conventional ERCP is not possible. More recently, EUS-FNI has been used to deliver specific anti-tumor agents for pancreatic cyst ablation and local control of tumor growth in patients with unresectable solid malignancies. The agents used to date include ethanol, brachytherapy seeds, and chemotherapeutic agents such as paclitaxel. In addition, FNI of new immunomodulating cell cultures such as mixed lymphocyte and dendritic cell cultures has also been reported, as has FNI of several different viral vectors for antitumor therapy. Although experience with these agents remains preliminary, EUS-FNI is a minimally invasive approach to deliver local antitumor agents, and is likely to have an expanding role in cancer therapy.
机译：内窥镜超声检查（EUS）对许多恶性肿瘤的诊断和分期至关重要，但现在在癌症治疗中具有不断发展的作用。 EUS引导的细针注射（FNI）已用于姑息性干预措施，例如通过神经阻滞治疗疼痛，并在无法使用常规ERCP时指导胆道减压。最近，EUS-FNI已被用于为无法切除的实体恶性肿瘤患者提供胰腺囊肿消融和局部控制肿瘤生长的特异性抗肿瘤药物。迄今为止使用的试剂包括乙醇，近距离放射治疗的种子和化疗剂，例如紫杉醇。另外，也已经报道了新的免疫调节细胞培养物，例如混合淋巴细胞和树突状细胞培养物的FNI，以及几种用于抗肿瘤治疗的不同病毒载体的FNI。尽管使用这些药物的经验仍然是初步的，但EUS-FNI是提供局部抗肿瘤药物的微创方法，并且可能在癌症治疗中发挥越来越大的作用。

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